Human antibodies against noncircumsporozoite proteins block Plasmodium falciparum parasite development in hepatocytes

Human antibodies against noncircumsporozoite proteins block Plasmodium falciparum parasite development in hepatocytes

Sporozoite-based approaches currently represent the most effective vaccine strategies for induction of sterile protection against Plasmodium falciparum (Pf) malaria. Clinical development of subunit vaccines is almost exclusively centered on the circum-sporozoite protein (CSP), an abundantly expresse...

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Bibliographic Details
Main Authors: Amanda Fabra-García, Annie S.P. Yang, Marije C. Behet, Zen Yap, Youri van Waardenburg, Swarnendu Kaviraj, Kjerstin Lanke, Geert-Jan van Gemert, Matthijs M. Jore, Teun Bousema, Robert W. Sauerwein
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-03-01
Series:JCI Insight
Subjects:
Infectious disease
Vaccines
Online Access:https://doi.org/10.1172/jci.insight.153524

Internet

https://doi.org/10.1172/jci.insight.153524

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