Neoantigen‐based cancer vaccination using chimeric RNA‐loaded dendritic cell‐derived extracellular vesicles

Neoantigen‐based cancer vaccination using chimeric RNA‐loaded dendritic cell‐derived extracellular vesicles

Abstract Cancer vaccines critically rely on the availability of targetable immunogenic cancer‐specific neoepitopes. However, mutation‐based immunogenic neoantigens are rare or even non‐existent in subgroups of cancer types. To address this issue, we exploited a cancer‐specific aberrant transcription...

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Bibliographic Details
Main Authors: Xiao Xiong, Xiurong Ke, Lu Wang, Yusheng Lin, Shuhong Wang, Zhimeng Yao, Kai Li, Yichen Luo, Fan Liu, Yunlong Pan, Sai‐Ching J. Yeung, Wijnand Helfrich, Hao Zhang
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Journal of Extracellular Vesicles
Subjects:
EV‐based cancer vaccine
mutation‐independent neoantigen
transcription‐induced chimeric RNA
Online Access:https://doi.org/10.1002/jev2.12243

Internet

https://doi.org/10.1002/jev2.12243

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