Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders.

Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders.

Although gene-gene interaction, or epistasis, plays a large role in complex traits in model organisms, genome-wide by genome-wide searches for two-way interaction have limited power in human studies. We thus used knowledge of a biological pathway in order to identify a contribution of epistasis to a...

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Bibliographic Details
Main Authors: Ileena Mitra, Alinoë Lavillaureix, Erika Yeh, Michela Traglia, Kathryn Tsang, Carrie E Bearden, Katherine A Rauen, Lauren A Weiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5226683?pdf=render

Internet

http://europepmc.org/articles/PMC5226683?pdf=render

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