Ketamine for pain [version 1; referees: 2 approved]
The efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as an analgesic agent is still under debate, especially for indications such as chronic pain. To understand the efficacy of ketamine for relief of pain, we performed a literature search for relevant narrative and systematic review...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-09-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-1711/v1 |
| _version_ | 1828838331247493120 |
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| author | Kelly Jonkman Albert Dahan Tine van de Donk Leon Aarts Marieke Niesters Monique van Velzen |
| author_facet | Kelly Jonkman Albert Dahan Tine van de Donk Leon Aarts Marieke Niesters Monique van Velzen |
| author_sort | Kelly Jonkman |
| collection | DOAJ |
| description | The efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as an analgesic agent is still under debate, especially for indications such as chronic pain. To understand the efficacy of ketamine for relief of pain, we performed a literature search for relevant narrative and systematic reviews and meta-analyses. We retrieved 189 unique articles, of which 29 were deemed appropriate for use in this review. Ketamine treatment is most effective for relief of postoperative pain, causing reduced opioid consumption. In contrast, for most other indications (that is, acute pain in the emergency department, prevention of persistent postoperative pain, cancer pain, and chronic non-cancer pain), the efficacy of ketamine is limited. Ketamine’s lack of analgesic effect was associated with an increase in side effects, including schizotypical effects. |
| first_indexed | 2024-12-12T19:00:30Z |
| format | Article |
| id | doaj.art-2443a56e5374468795bf35cee4919ff7 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T19:00:30Z |
| publishDate | 2017-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-2443a56e5374468795bf35cee4919ff72022-12-22T00:15:06ZengF1000 Research LtdF1000Research2046-14022017-09-01610.12688/f1000research.11372.112276Ketamine for pain [version 1; referees: 2 approved]Kelly Jonkman0Albert Dahan1Tine van de Donk2Leon Aarts3Marieke Niesters4Monique van Velzen5Department of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, NetherlandsDepartment of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, NetherlandsDepartment of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, NetherlandsDepartment of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, NetherlandsDepartment of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, NetherlandsDepartment of Anesthesiology, Anesthesia & Pain Research Unit, Leiden University Medical Center, Leiden, NetherlandsThe efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as an analgesic agent is still under debate, especially for indications such as chronic pain. To understand the efficacy of ketamine for relief of pain, we performed a literature search for relevant narrative and systematic reviews and meta-analyses. We retrieved 189 unique articles, of which 29 were deemed appropriate for use in this review. Ketamine treatment is most effective for relief of postoperative pain, causing reduced opioid consumption. In contrast, for most other indications (that is, acute pain in the emergency department, prevention of persistent postoperative pain, cancer pain, and chronic non-cancer pain), the efficacy of ketamine is limited. Ketamine’s lack of analgesic effect was associated with an increase in side effects, including schizotypical effects.https://f1000research.com/articles/6-1711/v1Emergency MedicineNeuropharmacology & PsychopharmacologyPain Management: Acute ClinicalPerioperative Critical CarePharmacokinetics & Drug Delivery |
| spellingShingle | Kelly Jonkman Albert Dahan Tine van de Donk Leon Aarts Marieke Niesters Monique van Velzen Ketamine for pain [version 1; referees: 2 approved] F1000Research Emergency Medicine Neuropharmacology & Psychopharmacology Pain Management: Acute Clinical Perioperative Critical Care Pharmacokinetics & Drug Delivery |
| title | Ketamine for pain [version 1; referees: 2 approved] |
| title_full | Ketamine for pain [version 1; referees: 2 approved] |
| title_fullStr | Ketamine for pain [version 1; referees: 2 approved] |
| title_full_unstemmed | Ketamine for pain [version 1; referees: 2 approved] |
| title_short | Ketamine for pain [version 1; referees: 2 approved] |
| title_sort | ketamine for pain version 1 referees 2 approved |
| topic | Emergency Medicine Neuropharmacology & Psychopharmacology Pain Management: Acute Clinical Perioperative Critical Care Pharmacokinetics & Drug Delivery |
| url | https://f1000research.com/articles/6-1711/v1 |
| work_keys_str_mv | AT kellyjonkman ketamineforpainversion1referees2approved AT albertdahan ketamineforpainversion1referees2approved AT tinevandedonk ketamineforpainversion1referees2approved AT leonaarts ketamineforpainversion1referees2approved AT mariekeniesters ketamineforpainversion1referees2approved AT moniquevanvelzen ketamineforpainversion1referees2approved |