Chiral Discrimination of Mexiletine Enantiomers by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors and Experimental Design Method Optimization

Mexiletine (MXL) is a class IB antiarrhythmic agent, acting as a non-selective voltage-gated sodium channel blocker, used in therapy as a racemic mixture <i>R</i>,<i>S</i>-MXL hydrochloride. The aim of the current study was the development of a new, fast, and efficient method...

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Bibliographic Details
Main Authors: Melania Cârcu-Dobrin, Gabriel Hancu, Lajos Attila Papp, Ibolya Fülöp
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/27/17/5603