In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury

In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury

PurposeAKT1 is an important target in sepsis acute lung injury (SALI). The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database (https://www.chemdiv.com/complete-list/) and use the system to screen for AKT1 activation agents, which may provide clu...

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Bibliographic Details
Main Authors: Ziyi Wang, Xuesong Wang, Zhe Guo, Haiyan Liao, Yan Chai, Ziwen Wang, Zhong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
sepsis
lung injury
HTS - high throughput satellite
apoptosis
AKT1
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1050497/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.1050497/full

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