Mechanistic insights into multiple-step transport of mitochondrial ADP/ATP carrier

Mechanistic insights into multiple-step transport of mitochondrial ADP/ATP carrier

The ADP/ATP carrier (AAC) is crucial for mitochondrial functions by importing ADP and exporting ATP across the inner mitochondrial membrane. However, the mechanism of highly specific ADP recognition and transport by AAC remains largely elusive. In this work, spontaneous ADP binding process to the gr...

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Bibliographic Details
Main Authors: Shihao Yao, Qiuzi Yi, Boyuan Ma, Xiaoting Mao, Ye Chen, Min-Xin Guan, Xiaohui Cang
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Transporter
Mitochondrial ADP
ATP translocases
Solute carrier family 25, molecular dynamics simulation
Substrate recognition
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022001076

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http://www.sciencedirect.com/science/article/pii/S2001037022001076

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