The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of the Hippo pathway in this disease; however, the molecular mechanisms wher...

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Main Authors: Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella, Gianluigi Giannelli, Frank Dombrowski, Matthias Evert, Diego F. Calvisi, Xin Chen, Katja Evert
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Intrahepatic cholangiocarcinoma
Hippo pathway
TAZ
AKT
Notch
TEAD transcription factors
Online Access:https://doi.org/10.1186/s13046-022-02394-2

Internet

https://doi.org/10.1186/s13046-022-02394-2

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