Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery

Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery

The human macula is more susceptible than the peripheral retina to developing blinding conditions such as age-related macular degeneration, diabetic retinopathy. A key difference between them may be the nature of their Müller cells. We found primary cultured Müller cells from macula and peripheral r...

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Bibliographic Details
Main Authors: Ting Zhang, Ling Zhu, Michele C Madigan, Wei Liu, Weiyong Shen, Svetlana Cherepanoff, Fanfan Zhou, Shaoxue Zeng, Jianhai Du, Mark C Gillies
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
de novo serine synthesis
macula
Müller cells
phosphoglycerate dehydrogenase
reactive oxygen species
Online Access:https://elifesciences.org/articles/43598

Internet

https://elifesciences.org/articles/43598

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