Genetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa

Genetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa

Increased thermogenesis in brown adipose tissue might have an obesity-reducing effect in humans. In transgenic mice, depletion of genes involved in creatine metabolism results in disrupted thermogenic capacity and altered effects of high-fat feeding on body weight. Data analyses of a sex-stratified...

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Bibliographic Details
Main Authors: Luisa S. Rajcsanyi, Anne Hoffmann, Adhideb Ghosh, Birgit Matrisch-Dinkler, Yiran Zheng, Triinu Peters, Wenfei Sun, Hua Dong, Falko Noé, Christian Wolfrum, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stephan Zipfel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Linus T. Tsai, Timo D. Müller, Matthias Blüher, Johannes Hebebrand, Raphael Hirtz, Anke Hinney
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Genetics
Subjects:
GWAS
creatine metabolism
in silico
BAT
TDT
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1128133/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1128133/full

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