Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody

Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody

The targeted delivery of therapies to diseased tissues offers a safe opportunity to achieve optimal efficacy while limiting systemic exposure. These considerations apply to many disease indications but are especially relevant for rheumatoid arthritis (RA), as RA is a systemic autoimmune disease whic...

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Bibliographic Details
Main Authors: Louise M. Topping, Bethan L. Thomas, Hefin I. Rhys, Jordi L. Tremoleda, Martyn Foster, Michael Seed, Mathieu-Benoit Voisin, Chiara Vinci, Hannah L. Law, Mauro Perretti, Lucy V. Norling, Helena S. Azevedo, Ahuva Nissim
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
extracellular vesicles (EV)
monoclonal antibodies
anti-TNF
collagen II
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00010/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00010/full

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