Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance

Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance

Multidrug resistance (MDR) remains one of the major reasons for inefficiency of many chemotherapeutic agents in cancer therapy. In this study, a D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and polylysine-deoxycholic acid copolymer (PLL-DA) co-modified cationic liposome coating with hyal...

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Bibliographic Details
Main Authors: Meng Lei, Guanglan Ma, Sijia Sha, Xueyuan Wang, Haiting Feng, Yongqiang Zhu, Xiao Du
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
multidrug resistance
liposome
combination therapy
tumor targeting capability
nanomedicine
Online Access:http://dx.doi.org/10.1080/10717544.2019.1580797

Internet

http://dx.doi.org/10.1080/10717544.2019.1580797

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