A dynamic Boolean network reveals that the BMI1 and MALAT1 axis is associated with drug resistance by limiting miR-145-5p in non-small cell lung cancer

A dynamic Boolean network reveals that the BMI1 and MALAT1 axis is associated with drug resistance by limiting miR-145-5p in non-small cell lung cancer

Patients with non-small cell lung cancer (NSCLC) are often treated with chemotherapy. Poor clinical response and the onset of chemoresistance limit the anti-tumor benefits of drugs such as cisplatin. According to recent research, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a l...

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Bibliographic Details
Main Authors: Shantanu Gupta, Daner A. Silveira, Gabriel P.S. Piedade, Miguel P. Ostrowski, José Carlos M. Mombach, Ronaldo F. Hashimoto
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Non-coding RNA Research
Subjects:
Drug resistance
NSCLC
MALAT1
miR-145
Positive feedback loops
BMI1
Online Access:http://www.sciencedirect.com/science/article/pii/S2468054023000690

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http://www.sciencedirect.com/science/article/pii/S2468054023000690

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