Cathepsin K activity controls cardiotoxin‐induced skeletal muscle repair in mice

Cathepsin K activity controls cardiotoxin‐induced skeletal muscle repair in mice

Abstract Background Cathepsin K (CatK) is a widely expressed cysteine protease that has gained attention because of its enzymatic and non‐enzymatic functions in signalling. Here, we examined whether CatK‐deficiency (CatK−/−) would mitigate injury‐related skeletal muscle remodelling and fibrosis in m...

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Bibliographic Details
Main Authors: Shinyu Ogasawara, Xian Wu Cheng, Aiko Inoue, Lina Hu, Limei Piao, Chenglin Yu, Hiroki Goto, Wenhu Xu, Guangxian Zhao, Yanna Lei, Guang Yang, Kaoru Kimura, Hiroyuki Umegaki, Guo‐Ping Shi, Masafumi Kuzuya
Format: Article
Language:English
Published: Wiley 2018-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Cathepsin K
Apoptosis
Skeletal muscle
Injury
Remodelling
Fibrosis
Online Access:https://doi.org/10.1002/jcsm.12248

Internet

https://doi.org/10.1002/jcsm.12248

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