Cancer associated variant enrichment CAVE, a gene agnostic approach to identify low burden variants in chronic lymphocytic leukemia

Cancer associated variant enrichment CAVE, a gene agnostic approach to identify low burden variants in chronic lymphocytic leukemia

Abstract Intratumoral heterogeneity is an important clinical challenge because low burden clones expressing specific genetic alterations drive therapeutic resistance mechanisms. We have developed CAVE (cancer-associated variant enrichment), a gene-agnostic computational tool to identify specific enr...

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Bibliographic Details
Main Authors: Adar Yaacov, Gregory Lazarian, Tatjana Pandzic, Simone Weström, Panagiotis Baliakas, Samia Imache, Valérie Lefebvre, Florence Cymbalista, Fanny Baran-Marszak, Shai Rosenberg, Thierry Soussi
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Scientific Reports
Subjects:
Low-frequency genetic variants
TP53
Chronic lymphocytic leukemia
Computational tool
Online Access:https://doi.org/10.1038/s41598-024-73027-1

Internet

https://doi.org/10.1038/s41598-024-73027-1

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