Brain volume loss in individuals over time: Source of variance and limits of detectability

Background: Brain volume loss measured from magnetic resonance imaging (MRI) is a marker of neurodegeneration and predictor of disability progression in MS, and is commonly used to assess drug efficacy at the group level in clinical trials. Whether measures of brain volume loss could be useful to he...

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Bibliographic Details
Main Authors: Sridar Narayanan, Kunio Nakamura, Vladimir S. Fonov, Josefina Maranzano, Zografos Caramanos, Paul S. Giacomini, D. Louis Collins, Douglas L. Arnold
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:NeuroImage
Online Access:http://www.sciencedirect.com/science/article/pii/S105381192030224X