Combined Inhibition of Polo-Like Kinase-1 and Wee1 as a New Therapeutic Strategy to Induce Apoptotic Cell Death in Neoplastic Mast Cells

Combined Inhibition of Polo-Like Kinase-1 and Wee1 as a New Therapeutic Strategy to Induce Apoptotic Cell Death in Neoplastic Mast Cells

Systemic mastocytosis (SM) is due to the pathologic accumulation of neoplastic mast cells in one or more extracutaneous organ(s). Although midostaurin, a multikinase inhibitor active against both wild-type and D816V-mutated KIT, improves organ damage and symptoms, a proportion of patients relapse or...

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Bibliographic Details
Main Authors: Manuela Mancini, Cecilia Monaldi, Sara De Santis, Michela Rondoni, Cristina Papayannidis, Chiara Sartor, Antonio Curti, Samantha Bruno, Michele Cavo, Simona Soverini
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
systemic mastocytosis
Aurora kinase A
Polo-like kinase 1
WEE1
Online Access:https://www.mdpi.com/2072-6694/14/3/738

Internet

https://www.mdpi.com/2072-6694/14/3/738

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