Recapitulating the Angiogenic Switch in a Hydrogel-Based 3D In Vitro Tumor-Stroma Model

Recapitulating the Angiogenic Switch in a Hydrogel-Based 3D In Vitro Tumor-Stroma Model

To ensure nutrient and oxygen supply, tumors beyond a size of 1–2 mm<sup>3</sup> need a connection to the vascular system. Thus, tumor cells modify physiological tissue homeostasis by secreting inflammatory and angiogenic cytokines. This leads to the activation of the tumor microenvironm...

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Bibliographic Details
Main Authors: Claudia Kuehlbach, Sabine Hensler, Margareta M. Mueller
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Bioengineering
Subjects:
angiogenesis
tubular structures
vascular sprouting
high-throughput 3D tumor-stroma model
tumor–stroma interaction
dextran hydrogel
Online Access:https://www.mdpi.com/2306-5354/8/11/186

Internet

https://www.mdpi.com/2306-5354/8/11/186

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