Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

Abstract Background G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except for a few chemokine receptors, regulate the progression of liver fibrosis. Here, we aimed to reveal the role of GPR65, a proton-sensi...

Full description

Bibliographic Details
Main Authors: Kun Zhang, Meng-Xia Zhang, Xiao-Xiang Meng, Jing Zhu, Jia-Jun Wang, Yi-Fan He, Ye-Hua Li, Si-Cong Zhao, Zhe-Min Shi, Li-Na Zheng, Tao Han, Wei Hong
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Military Medical Research
Subjects:
GPR65
Hepatic fibrosis
Hepatic macrophages
Inflammation
JNK
NF-κB
Online Access:https://doi.org/10.1186/s40779-023-00494-4

Internet

https://doi.org/10.1186/s40779-023-00494-4

Similar Items