Multicolour single molecule imaging in cells with near infra-red dyes.

The autofluorescence background of biological samples impedes the detection of single molecules when imaging. The most common method of reducing the background is to use evanescent field excitation, which is incompatible with imaging beyond the surface of biological samples. An alternative would be...

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Bibliographic Details
Main Authors: Christopher J Tynan, David T Clarke, Benjamin C Coles, Daniel J Rolfe, Marisa L Martin-Fernandez, Stephen E D Webb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338497?pdf=render