The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A

The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A

Mutations in activin-like kinase 2 (ALK2), e.g., ALK2-R206H, induce aberrant signaling to SMAD1/5/8, leading to Fibrodysplasia Ossificans Progressiva (FOP). In spite of extensive studies, the underlying mechanism is still unclear. Here, we quantified the homomeric and heteromeric interactions of ACV...

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Bibliographic Details
Main Authors: Szabina Szófia Szilágyi, Wiktor Burdzinski, Jerome Jatzlau, Marcelo Ehrlich, Petra Knaus, Yoav I. Henis
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
ALK2
ALK2-R206H
activin receptors
FOP (fibrodysplasia ossificans progressiva)
activin A
FRAP
Online Access:https://www.mdpi.com/2073-4409/13/3/221

Internet

https://www.mdpi.com/2073-4409/13/3/221

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