The Discovery of Novel Agents against <i>Staphylococcus aureus</i> by Targeting Sortase A: A Combination of Virtual Screening and Experimental Validation

<i>Staphylococcus aureus (S. aureus)</i>, commonly known as “superbugs”, is a highly pathogenic bacterium that poses a serious threat to human health. There is an urgent need to replace traditional antibiotics with novel drugs to combat <i>S. aureus</i>. Sortase A (SrtA) is a...

Full description

Bibliographic Details
Main Authors: Kang Liu, Jiangbo Tong, Xu Liu, Dan Liang, Fangzhe Ren, Nan Jiang, Zhenyu Hao, Shixin Li, Qiang Wang
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceuticals
Subjects:
Online Access:https://www.mdpi.com/1424-8247/17/1/58