Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network.
Biochemical pathways are often genetically encoded as simple transcription regulation networks, where one transcription factor regulates the expression of multiple genes in a pathway. The relative timing of each promoter's activation and shut-off within the network can impact physiology. In the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-06-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5999292?pdf=render |