Co-transducing B7H3 CAR-NK cells with the DNR preserves their cytolytic function against GBM in the presence of exogenous TGF-β

Co-transducing B7H3 CAR-NK cells with the DNR preserves their cytolytic function against GBM in the presence of exogenous TGF-β

Cord blood (CB)-derived natural killer (NK) cells that are genetically engineered to express a chimeric antigen receptor (CAR) are an attractive off-the-shelf therapy for the treatment of cancer, demonstrating a robust safety profile in vivo. For poor prognosis brain tumors such as glioblastoma mult...

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Bibliographic Details
Main Authors: Kajal Chaudhry, Ashley Geiger, Ehsan Dowlati, Haili Lang, Danielle K. Sohai, Eugene I. Hwang, Christopher A. Lazarski, Eric Yvon, Matthias Holdhoff, Richard Jones, Barbara Savoldo, Conrad Russell Y. Cruz, Catherine M. Bollard
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
cord blood
NK cells
CAR-NK cells
B7H3 CAR
GBM
TGF-β
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001528

Internet

http://www.sciencedirect.com/science/article/pii/S2329050122001528

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