Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways

Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways

The ubiquitin-specific protease 7 (USP7), as a deubiquitinating enzyme, plays an important role in tumor progression by various mechanisms and serves as a potential therapeutic target. However, the functional role of USP7 in melanoma remains elusive. Here, we found that USP7 is overexpressed in huma...

Full description

Bibliographic Details
Main Authors: Lanyang Gao, Danli Zhu, Qin Wang, Zheng Bao, Shigang Yin, Huiyan Qiang, Heinrich Wieland, Jinyue Zhang, Alexander Teichmann, Jing Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
melanoma
USP7
deubiquitinating enzyme
quantitative proteomics
PI3K/Akt/FOXO pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.650165/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.650165/full

Similar Items