A case–control study of BRCA1 founder mutations 185delAG and 5382insC in a cohort of Egyptian ovarian cancer patients using pyrosequencing technique

A case–control study of BRCA1 founder mutations 185delAG and 5382insC in a cohort of Egyptian ovarian cancer patients using pyrosequencing technique

Abstract Background Ovarian cancer (OC) is considered a leading cause of death among women with gynecological malignancies. OC, like breast cancer, shows a familial predisposition to germline mutations in genes BRCA1 or BRCA2, which have proved to play important roles in the incidence and progressio...

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Bibliographic Details
Main Authors: Mohamed M. Rizk, Nour M. El-etreby, Lama M. El-Attar, Eman A. Elzyat, Marwa H. Saied
Format: Article
Language:English
Published: SpringerOpen 2022-01-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Familial ovarian cancer
BRCA1 gene
BRCA2 gene
Founder mutation
Pyrosequencing
Online Access:https://doi.org/10.1186/s43042-022-00226-8

Internet

https://doi.org/10.1186/s43042-022-00226-8

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