Mechanical activation of the angiotensin II type 1 receptor contributes to abdominal aortic aneurysm formation

Mechanical activation of the angiotensin II type 1 receptor contributes to abdominal aortic aneurysm formation

Objective: The angiotensin II type 1 receptor (AT1R) can be activated under conditions of mechanical stretch in some cellular systems. Whether this activity influences signaling within the abdominal aorta to promote to abdominal aortic aneurysm (AAA) development remains unknown. We evaluated the hyp...

Full description

Bibliographic Details
Main Authors: SarahRose Hall, BA, Nicholas D. Ward, MD, Raj Patel, BS, Armaan Amin-Javaheri, BS, Hayes Lanford, BS, R. Tyler Grespin, MS, Christine Couch, MS, Ying Xiong, PhD, Rupak Mukherjee, PhD, Jeffrey A. Jones, PhD, Jean Marie Ruddy, MD
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:JVS - Vascular Science
Subjects:
Aortic aneurysm
Angiotensin II type 1 receptor
Losartan
Vascular remodeling
Hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S266635032100016X

Internet

http://www.sciencedirect.com/science/article/pii/S266635032100016X

Similar Items