Flavonoid derivatives treat dextran sodium sulfate-induced experimental colitis in mice by inhibiting MAPK/NF-κB pathway activation

Flavonoid derivatives treat dextran sodium sulfate-induced experimental colitis in mice by inhibiting MAPK/NF-κB pathway activation

Flavonoids are widely found in plants and diets and are considered to possess a variety of biological activities. Therefore, in this study, 8 novel compounds derivating from the precursor compound 1a, were designed and synthesized, and their activities against ulcerative colitis(UC) were evaluated t...

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Bibliographic Details
Main Authors: Cen Xiang, Quanyuan Qiu, Chunmei Zhang, Yandong Leng, Mengzhen Yuan, Yao Rong, Futao Liu, Lianbo Zhao, Zhen Liu, Yunsong Chang, Yu-Ou Teng
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Flavonoid derivatives
Anti-Inflammatory
Ulcerative colitis
Intestinal flora
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424000682

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http://www.sciencedirect.com/science/article/pii/S2772417424000682

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