Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA replication in pathogenic microorganisms. Clost...

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Bibliographic Details
Main Authors: Erika van Eijk, Vasileios Paschalis, Matthew Green, Annemieke H. Friggen, Marilynn A. Larson, Keith Spriggs, Geoffrey S. Briggs, Panos Soultanas, Wiep Klaas Smits
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
dna replication initiation
helicase loading and activation
primase trinucleotide specificity
atpase
clostridium difficile
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160272

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160272

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