Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and prevent viral neutralization. Here, we used a...

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Bibliographic Details
Main Authors: Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Immunology
Virology
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222011865

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222011865

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