Screening the NCI diversity set V for anti-MRSA activity: cefoxitin synergy and LC-MS/MS confirmation of folate/thymidine biosynthesis inhibition

Screening the NCI diversity set V for anti-MRSA activity: cefoxitin synergy and LC-MS/MS confirmation of folate/thymidine biosynthesis inhibition

ABSTRACT New antibacterial agents and agent combinations are urgently needed to combat antimicrobial resistance. A multidimensional chemical library screening strategy was used to identify compounds in the National Cancer Institute (NCI) diversity set V library (1,593 compounds) with anti-methicilli...

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Bibliographic Details
Main Authors: Shivani Gargvanshi, Gioia Heravi, Navid J. Ayon, William G. Gutheil
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
library screening
Staphylococcus aureus
microsome
P450
metabolism
drug discovery
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00541-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00541-23

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