Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study

Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study

Abstract Background In patients with severe polycystic liver disease (PLD), there is a need for new treatments. Estrogens and possibly other female sex hormones stimulate growth in PLD. In some patients, liver volume decreases after menopause. Female sex hormones could therefore be a target for ther...

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Bibliographic Details
Main Authors: S. E. Aapkes, L. H. P. Bernts, A. P. van den Berg, M. van den Berg, H. Blokzijl, A. E. P. Cantineau, M. D. A. van Gastel, R. J. de Haas, P. Kappert, R. U. Müller, F. Nevens, R. Torra, A. Visser, J. P. H. Drenth, R. T. Gansevoort
Format: Article
Language:English
Published: BMC 2022-02-01
Series:BMC Gastroenterology
Subjects:
Polycystic liver disease
GnRHa
Estrogen
Online Access:https://doi.org/10.1186/s12876-022-02142-y

Internet

https://doi.org/10.1186/s12876-022-02142-y

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