Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity

Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity

Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead molecular-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance and adverse effects, new inhibitors of ABL kinase are needed. Our previous study showed that the benzyl ester of gypsogenin (<b>1c</...

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Bibliographic Details
Main Authors: Halil I. Ciftci, Mohamed O. Radwan, Safiye E. Ozturk, N. Gokce Ulusoy, Ece Sozer, Doha E. Ellakwa, Zeynep Ocak, Mustafa Can, Taha F.S. Ali, Howaida I. Abd-Alla, Nurettin Yayli, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
leukemia
chronic myelogenous leukemia
abl kinase
pentacyclic triterpenes
gypsogenin
apoptosis
Online Access:https://www.mdpi.com/1420-3049/24/19/3535

Internet

https://www.mdpi.com/1420-3049/24/19/3535

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