SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation

SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation

The p38 inhibitor SB202190 is a necessary component of the medium used for normal colorectal mucosa cultures. Sato et al. suggested that the primary activity of SB202190 may be EGFR signaling stabilization, causing an increased phosphorylation of Erk1-2 sustaining organoid proliferation. However, th...

Full description

Bibliographic Details
Main Authors: Delfina Costa, Roberta Venè, Simona Coco, Luca Longo, Francesca Tosetti, Stefano Scabini, Luca Mastracci, Federica Grillo, Alessandro Poggi, Roberto Benelli
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
colorectal cancer
organoid
SB202190
BRAF
Erk1-2
Online Access:https://www.mdpi.com/2073-4409/12/4/664

Internet

https://www.mdpi.com/2073-4409/12/4/664

Similar Items