Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators
Abstract G-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achieve satisfactory sensitivity. Here, we use frequen...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-51320-x |