Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis

Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis

ABSTRACT Visceral leishmaniasis (VL) is a potentially fatal disease caused mainly by Leishmania infantum in South America and Leishmania donovani in Asia and Africa. Disease outcomes have been associated with patient genotype, nutrition, age, sex, comorbidities, and coinfections. In this study, we e...

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Main Authors: Cooper Alastair Grace, Kátia Silene Sousa Carvalho, Mayara Ingrid Sousa Lima, Vladimir Costa Silva, João Luís Reis-Cunha, Matthew J. Brune, Sarah Forrester, Conceição de Maria Pedrozo e Silva de Azevedo, Dorcas Lamounier Costa, Doug Speed, Jeremy C. Mottram, Daniel C. Jeffares, Carlos H. N. Costa
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
visceral leishmaniasis
Brazil
Leishmania infantum
virulence factors
genetic diversity
quantitative genetics
Online Access:https://journals.asm.org/doi/10.1128/mbio.02068-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02068-22

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