Interdiction in the Early Folding of the p53 DNA-Binding Domain Leads to Its Amyloid-Like Misfolding

Interdiction in the Early Folding of the p53 DNA-Binding Domain Leads to Its Amyloid-Like Misfolding

In this article, we investigate two issues: (a) the initial contact formation events along the folding pathway of the DNA-binding domain of the tumor suppressor protein p53 (core p53); and (b) the intermolecular events leading to its conversion into a prion-like form upon incubation with peptide P8(...

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Bibliographic Details
Main Authors: Fernando Bergasa-Caceres, Herschel A. Rabitz
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
cancer
prion
folding
pathway
interdiction
peptide
Online Access:https://www.mdpi.com/1420-3049/27/15/4810

Internet

https://www.mdpi.com/1420-3049/27/15/4810

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