Genomic DNA copy-number alterations of the let-7 family in human cancers.

Genomic DNA copy-number alterations of the let-7 family in human cancers.

In human cancer, expression of the let-7 family is significantly reduced, and this is associated with shorter survival times in patients. However, the mechanisms leading to let-7 downregulation in cancer are still largely unclear. Since an alteration in copy-number is one of the causes of gene dereg...

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Bibliographic Details
Main Authors: Yanling Wang, Xiaowen Hu, Joel Greshock, Liang Shen, Xiaojun Yang, Zhongjun Shao, Shun Liang, Janos L Tanyi, Anil K Sood, Lin Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3435307?pdf=render

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http://europepmc.org/articles/PMC3435307?pdf=render

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