Certainty in uncertainty: Determining the rate and reasons for reclassification of variants of uncertain significance in haematological malignancies

Certainty in uncertainty: Determining the rate and reasons for reclassification of variants of uncertain significance in haematological malignancies

Abstract Introduction Variants of uncertain significance (VUS) are commonly reported in cancer with the widespread adoption of diagnostic massive parallel sequencing. The rate of reclassification of VUS in patients with haematological malignancy is not known and we evaluated this retrospectively. We...

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Bibliographic Details
Main Authors: Anoop K. Enjeti, Natasha Walker, Oliver Fahey, Elizabeth Johnston, Hannah Legge‐Wilkinson, Nateika Ramsurrun, Jonathan Sillar, Lisa F. Lincz, Andrew Ziolkowski, David Mossman
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:eJHaem
Subjects:
haematological malignancy
leukaemia
massive parallel sequencing
reclassification
variants of uncertain significance
Online Access:https://doi.org/10.1002/jha2.1002

Internet

https://doi.org/10.1002/jha2.1002

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