The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation

The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation

Acne vulgaris has a pathogenesis that involves increased sebum production and perifollicular inflammation. Sterol regulatory element-binding protein-1 (SREBP-1) and peroxisome proliferator activated receptor-γ (PPAR-γ) are transcription factors that regulate numerous genes involved in lipid biosynth...

Full description

Bibliographic Details
Main Authors:	Hyemin Gu, Hyun-Jin An, Mi-Gyeong Gwon, Seongjae Bae, Christos C. Zouboulis, Kwan-Kyu Park
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Biomolecules
Subjects:	decoy oligodeoxynucleotide lipogenic regulation peroxisome proliferator activated receptor-γ sterol regulatory element-binding protein-1
Online Access:	https://www.mdpi.com/2218-273X/12/12/1858

Similar Items

Antifibrotic Effect of Smad Decoy Oligodeoxynucleotide in a CCl4-Induced Hepatic Fibrosis Animal Model
by: Mi-Gyeong Gwon, et al.
Published: (2018-08-01)

The decoy oligodeoxynucleotide against HIF-1α and STAT5 ameliorates atopic dermatitis-like mouse model
by: Mi-Gyeong Gwon, et al.
Published: (2023-12-01)

Anti-Fibrotic Effect of Synthetic Noncoding Oligodeoxynucleotide for Inhibiting mTOR and STAT3 via the Regulation of Autophagy in an Animal Model of Renal Injury
by: Hyun Jin Jung, et al.
Published: (2022-01-01)

Nuclear Factor-κB Decoy Oligodeoxynucleotide Attenuates Cartilage Resorption In Vitro
by: Hitoshi Nemoto, et al.
Published: (2024-01-01)

Harnessing the Therapeutic Potential of Decoys in Non-Atherosclerotic Cardiovascular Diseases: State of the Art
by: Maryam Mahjoubin-Tehran, et al.
Published: (2021-08-01)

Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells modified with NF-κB decoy oligodeoxynucleotides
by: Jiang HM, et al.
Published: (2017-10-01)

STAT3 Decoy Oligodeoxynucleotides Suppress Liver Inflammation and Fibrosis in Liver Cancer Cells and a DDC-Induced Liver Injury Mouse Model
by: Hye Jin Choi, et al.
Published: (2024-01-01)

Advances in the mechanisms and applications of inhibitory oligodeoxynucleotides against immune-mediated inflammatory diseases
by: Hongrui Wang, et al.
Published: (2023-02-01)

Inhibitory Effects of STAT3 Transcription Factor by Synthetic Decoy ODNs on Autophagy in Renal Fibrosis
by: Young-Ah Kim, et al.
Published: (2021-03-01)

Prevention of Asthma Exacerbation in a Mouse Model by Simultaneous Inhibition of NF-κB and STAT6 Activation Using a Chimeric Decoy Strategy
by: Tetsuo Miyake, et al.
Published: (2018-03-01)

Hyperglobus and Pseudoptosis in Type 1 Lipogenic Thyroid Eye Disease
by: Amee D. Azad, et al.
Published: (2023-12-01)

Synthesis of Oligodeoxynucleotides Using Fully Protected Deoxynucleoside 3′-Phosphoramidite Building Blocks and Base Recognition of Oligodeoxynucleotides Incorporating N3-Cyano-Ethylthymine
by: Mitsuo Sekine, et al.
Published: (2010-10-01)

SREBP-1-independent regulation of lipogenic gene expression in adipocytes
by: Motohiro Sekiya, et al.
Published: (2007-07-01)

DETECTION OF COMPLEXES OLIGODEOXYNUCLEOTIDES WITH POLYMERIC CARRIERS
by: V. V. Vlizlo, et al.
Published: (2013-10-01)

Changing Decisions: The Interaction between Framing and Decoy Effects
by: Adolfo Di Crosta, et al.
Published: (2023-09-01)

Comparison of false-discovery rates of various decoy databases
by: Sangjeong Lee, et al.
Published: (2021-09-01)

Class A CpG oligodeoxynucleotide inhibits IFN‐γ‐induced signaling and apoptosis in lung cancer
by: Shuhei Teranishi, et al.
Published: (2020-04-01)

Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis
by: Elke M. Wagner, et al.
Published: (2004-02-01)

Myogenetic Oligodeoxynucleotides as Anti-Nucleolin Aptamers Inhibit the Growth of Embryonal Rhabdomyosarcoma Cells
by: Naoki Nohira, et al.
Published: (2022-10-01)

An Integrated Algorithm for Designing Oligodeoxynucleotides for Gene Synthesis
by: Gang Fang, et al.
Published: (2022-03-01)

Effect of dietary fatty acids on expression of lipogenic enzymes and fatty acid profile in tissues of bulls
by: A. Herdmann, et al.
Published: (2010-01-01)

Contextual effects and psychological features influencing decoy options: A review and research agenda
by: David Gonzalez-Prieto, et al.
Published: (2013-01-01)

Synthetic Non-Coding RNA for Suppressing mTOR Translation to Prevent Renal Fibrosis Related to Autophagy in UUO Mouse Model
by: Young-Ah Kim, et al.
Published: (2022-09-01)

Glucogenic and lipogenic diets affect in vitro ruminal microbiota and metabolites differently
by: Dengke Hua, et al.
Published: (2022-12-01)

Effect of Feedingarginine on the Growth Performance, Carcass Traits, Relative Expression of Lipogenic Genes, and Blood Parametersof Arian Broilers
by: ZA Pirsaraei, et al.

Seasonal Consumption of Cherries from Different Origins Affects Metabolic Markers and Gene Expression of Lipogenic Enzymes in Rat Liver: A Preliminary Study
by: Ma. Josefina Ruiz de Azua, et al.
Published: (2021-10-01)

Effects of zinc supplementation and betaine substitution to methionine on hepatic betaine - homocysteine methyltransferase and lipogenic genes expression in laying hens under heat stress
by: Mahmood Naziri, et al.
Published: (2017-06-01)

DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancer
by: Geoffrey Casas, et al.
Published: (2022-09-01)

Decoy Technology as a Promising Therapeutic Tool for Atherosclerosis
by: Maryam Mahjoubin-Tehran, et al.
Published: (2021-04-01)

Target-small decoy search strategy for false discovery rate estimation
by: Hyunwoo Kim, et al.
Published: (2019-08-01)

NF-κB Decoy ODN-Loaded Poly(Lactic-co-glycolic Acid) Nanospheres Inhibit Alveolar Ridge Resorption
by: Albert chun-shuo Huang, et al.
Published: (2023-02-01)

Insulin-Related Lipohypertrophy: Lipogenic Action or Tissue Trauma?
by: Anjana Barola, et al.
Published: (2018-10-01)

Bee Venom and Its Major Component Melittin Attenuated <i>Cutibacterium acnes</i>- and IGF-1-Induced Acne Vulgaris via Inactivation of Akt/mTOR/SREBP Signaling Pathway
by: Hyemin Gu, et al.
Published: (2022-03-01)

Transfection of Vein Grafts with Early Growth Response Factor-1 Oligodeoxynucleotide Decoy: Effects on Stem-Cell Genes and Toll-like Receptor-Mediated Inflammation
by: Konstantinos S. Mylonas, et al.
Published: (2023-11-01)

INFLUENCE OF CpG ODN 2006 OLIGODEOXYNUCLEOTIDE ON CYTOKINE PRODUCTION BY BLOOD CELLS OF HUMANS VACCINATED AGAINST PLAGUE
by: S. N. Klyueva, et al.
Published: (2015-01-01)

Short hairpin-looped oligodeoxynucleotides reduce hepatitis C virus replication
by: Broecker Felix, et al.
Published: (2012-07-01)

Chronic Oleoylethanolamide Treatment Decreases Hepatic Triacylglycerol Level in Rat Liver by a PPARγ/SREBP-Mediated Suppression of Fatty Acid and Triacylglycerol Synthesis
by: Adele Romano, et al.
Published: (2021-01-01)

CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
by: Hanagata N
Published: (2017-01-01)

Serum Concentration of Soluble Decoy Receptor 3 in Glioma Patients Before and After Surgery
by: Shiuh-Lin Hwang, et al.
Published: (2004-03-01)

Myogenetic Oligodeoxynucleotide (myoDN) Recovers the Differentiation of Skeletal Muscle Myoblasts Deteriorated by Diabetes Mellitus
by: Shunichi Nakamura, et al.
Published: (2021-05-01)