Down syndrome is an oxidative phosphorylation disorder

Down syndrome is an oxidative phosphorylation disorder

Down syndrome is the most common genomic disorder of intellectual disability and is caused by trisomy of chromosome 21. Several genes in this chromosome repress mitochondrial biogenesis. The goal of this study was to evaluate whether early overexpression of these genes may cause a prenatal impairmen...

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Bibliographic Details
Main Authors: M. Pilar Bayona-Bafaluy, Nuria Garrido-Pérez, Patricia Meade, Eldris Iglesias, Irene Jiménez-Salvador, Julio Montoya, Carmen Martínez-Cué, Eduardo Ruiz-Pesini
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Redox Biology
Subjects:
Down syndrome
Brain development
Neurogenesis
Oxidative phosphorylation
Mitochondrial biogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000197

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http://www.sciencedirect.com/science/article/pii/S2213231721000197

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