Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV.

Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV.

HIV vaccine development has been hampered by issues such as undefined correlates of protection and extensive diversity of HIV. We addressed these issues using a previously established SIV-macaque model in which SIV mutants with deletions of multiple gp120 N-glycans function as potent live attenuated...

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Bibliographic Details
Main Authors: Chie Sugimoto, Satoru Watanabe, Taeko Naruse, Eiji Kajiwara, Teiichiro Shiino, Natsuko Umano, Kayoko Ueda, Hirotaka Sato, Shinji Ohgimoto, Vanessa Hirsch, Francois Villinger, Aftab A Ansari, Akinori Kimura, Masaaki Miyazawa, Yasuo Suzuki, Naoki Yamamoto, Yoshiyuki Nagai, Kazuyasu Mori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2907403?pdf=render

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http://europepmc.org/articles/PMC2907403?pdf=render

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