High Circulating Sonic Hedgehog Protein Is Associated With Poor Outcome in EGFR-Mutated Advanced NSCLC Treated With Tyrosine Kinase Inhibitors

High Circulating Sonic Hedgehog Protein Is Associated With Poor Outcome in EGFR-Mutated Advanced NSCLC Treated With Tyrosine Kinase Inhibitors

IntroductionGrowing preclinical evidence has suggested that the Sonic hedgehog (Shh) pathway is involved in resistance to tyrosine kinase inhibitor (TKI) therapy for EGFR-mutated (EGFRm) non-small cell lung cancer (NSCLC). However, little is known concerning the prognostic value of this pathway in t...

Full description

Bibliographic Details
Main Authors: Paul Takam Kamga, Aurélie Swalduz, Adrien Costantini, Catherine Julié, Jean-François Emile, Maurice Pérol, Virginie Avrillon, Sandra Ortiz-Cuaran, Pierre de Saintigny, Etienne Giroux-Leprieur
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer (NSCLC)
epidermal growth factor receptor (EGFR)
Sonic Hedgehog (Shh)
biomarker
tyrosine kinase inhibitor (TKI)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.747692/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.747692/full

Similar Items