Has the shortage of fludarabine altered the current paradigm of lymphodepletion in favor of bendamustine?

Has the shortage of fludarabine altered the current paradigm of lymphodepletion in favor of bendamustine?

The most common lymphodepletion regimen used prior to infusion of chimeric antigen receptor-T cells (CAR-T) is cyclophosphamide (CY) in combination with fludarabine (Flu) (CY-FLU). While cyclophosphamide (CY) possesses lymphotoxic effects, it concurrently preserves regulatory T cell activity, potent...

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Hlavní autoři: Dimitrios Filioglou, Muhammad Husnain, Sharad Khurana, Richard J. Simpson, Emmanuel Katsanis
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2023-11-01
Edice:Frontiers in Immunology
Témata:
fludarabine
cyclophosphamide
bendamustine
lymphodepletion
CAR (chimeric antigen receptor) T cells
On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1329850/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1329850/full

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