Localized semi-nonnegative matrix factorization (LocaNMF) of widefield calcium imaging data.

Widefield calcium imaging enables recording of large-scale neural activity across the mouse dorsal cortex. In order to examine the relationship of these neural signals to the resulting behavior, it is critical to demix the recordings into meaningful spatial and temporal components that can be mapped...

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Bibliographic Details
Main Authors: Shreya Saxena, Ian Kinsella, Simon Musall, Sharon H Kim, Jozsef Meszaros, David N Thibodeaux, Carla Kim, John Cunningham, Elizabeth M C Hillman, Anne Churchland, Liam Paninski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007791