NK cells associate with ALS in a sex- and age-dependent manner

NK cells are innate immune cells implicated in ALS; whether NK cells impact ALS in a sex- and age-specific manner was investigated. Herein, NK cells were depleted in male and female SOD1G93A ALS mice, survival and neuroinflammation were assessed, and data were stratified by sex. NK cell depletion ex...

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Bibliographic Details
Main Authors: Benjamin J. Murdock, Joshua P. Famie, Caroline E. Piecuch, Kristen D. Raue, Faye E. Mendelson, Cole H. Pieroni, Sebastian D. Iniguez, Lili Zhao, Stephen A. Goutman, Eva L. Feldman
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-06-01
Series:JCI Insight
Subjects:
Online Access:https://doi.org/10.1172/jci.insight.147129