Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

Alternative splicing of pre-mRNA contributes strongly to the diversity of cell- and tissue-specific protein expression patterns. Global transcriptome analyses have suggested that >90% of human multiexon genes are alternatively spliced. Alterations in the splicing process cause missplicing eve...

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Bibliographic Details
Main Authors: Marc Suñé-Pou, María J. Limeres, Cristina Moreno-Castro, Cristina Hernández-Munain, Josep M. Suñé-Negre, María L. Cuestas, Carlos Suñé
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Genetics
Subjects:
splicing
RNA
gene therapy and therapeutic delivery
siRNAs
ASOs
SMaRT
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00731/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00731/full

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