New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds

New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds

NAD<sup>+</sup>-dependent deacetylase SIRT1 regulates many different biological processes, thus being involved in pathogenic conditions such as metabolic diseases, neurogenerative disorders and cancer. Notably, experimental evidence underlined that the activation of SIRT1 had promising c...

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Bibliographic Details
Main Authors: Giulia Bononi, Lorenzo Flori, Valentina Citi, Cecilia Acciai, Viviana Nocilla, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
sirtuin 1
activators
I/R injury
cardioprotection
diarylamine
molecular modeling
Online Access:https://www.mdpi.com/1424-8247/15/3/339

Internet

https://www.mdpi.com/1424-8247/15/3/339

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