MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway

MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway

Abstract Background Neutrophilic airway inflammation is a challenge in asthma management and is associated with poor patient prognosis. Mucin 1 (MUC1), which contains a cytoplasmic tail (MUC1-CT), has been found to mediate glucocorticoid sensitivity in asthma; however, its role in modulating neutrop...

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Bibliographic Details
Main Authors: Lu Liu, Ling Zhou, Lingling Wang, Zhenyu Mao, Pengdou Zheng, Fengqin Zhang, Huojun Zhang, Huiguo Liu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Respiratory Research
Subjects:
Asthma
MUC1
Pyroptosis
Inflammation
Online Access:https://doi.org/10.1186/s12931-023-02550-y

Internet

https://doi.org/10.1186/s12931-023-02550-y

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