Establishment of a novel hepatitis B virus culture system using immortalized human hepatocytes

Abstract Recent development of hepatitis B virus (HBV) culture systems has made it possible to analyze the almost all steps of the viral life cycle. However, the reproducibility of interaction between HBV and host cells seemed inaccurate in those systems because of utilization of cancer cell lines w...

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Bibliographic Details
Main Authors: Yuichi Akahori, Hiroki Kato, Takashi Fujita, Kohji Moriishi, Yasuhito Tanaka, Koichi Watashi, Michio Imamura, Kazuaki Chayama, Takaji Wakita, Makoto Hijikata
Format: Article
Language:English
Published: Nature Portfolio 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78655-x